How Bonexcin™ Works

Wondering what you can do to reverse bone loss? Maintaining your bone density doesn’t have to be a guessing game when taking Bonexcin™. Having a regular exercise routine and not smoking is a great start to having and maintaining healthy bones, but giving your body vital ingredients like those in Bonexcin™, will ensure your bones stay as healthy as they can be. Bonexcin™ is a comprehensive formula designed to stimulate new bone cells, while preventing any new bone loss with its vital ingredients of minerals, trace elements and flavones. You don’t have to worry about any harmful additives or hormones, Bonexcin™ is all natural!

The Science Behind Bonexcin™

Ipriflavone- Provides an alternative to estrogen replacement therapy for treating low bone density or osteoporosis. It helps to generate osteogenesis, the formation of new bone.

Calcium Plus Vitamin D - Taking calcium combined with vitamin D is effective in reducing bone mineral density loss. Calcium is known to be a bone building mineral, and the advantages of taking it long term will help assist in reversing bone loss. Bone loss in premenopausal women over age 40 can be reduced significantly by supplementing their diet with calcium. Multiple clinical studies and meta-analysis suggest efficacy for calcium plus vitamin D for primary prevention of osteoporosis. The combination of calcium plus vitamin D was shown to significantly reduce the risk of hip fractures by about 29%.

Phosphorus - Phosphorus is critical to maintaining healthy bones, especially when combined with calcium supplements. Both minerals are essential in building new bone mass.

Zinc - Lower zinc intake and zinc serum levels are associated with lower Bone Mineral Density (BMD) in men and women. Taking zinc in combination with copper, manganese, and calcium can slow bone loss in postmenopausal women.

Vitamin K - Helps to increase Bone Mass Density (BMD)

Who Should Take Bonexcin™

• Those Who Have a Family History of Osteoporosis
• Women Who Are Pre-Menopausal or Post Menopausal
• Anyone Who Does Not Take in Enough Calcium
• Women Who Have Gone Through Early Menopause
• Women Who Have Had Their Ovaries Removed
• Anyone Who Has Been on Extended Bed Rest
• If You Have Taken Certain Medicines for a Long Time
• Women With Small Body Frames
• Both Men and Women at Risk for Bone Loss

You too can benefit from Bonexcin™ to insure deliver the protection you will need in your fight against the silent killer -osteoporosis!

How Long Should You Take Bonexcin™?

Bonexcin™ is an all natural supplement that should be used as part of your daily regimen to promote maximum bone protection.

Building A Healthier Body One Bone At A Time... Bonexcin™

Bonexcin Success Stories

I'm 68 years old and my mother and 2 sisters have osteoporosis.  Previously I was taking 3 different things to help reduce my risk of bone fractures. My cousin told me about Bonexcin™ because she has been taking it for several months. I absolutely love this product because I only have to remember to take 1 product. Bonexcin™ has made it easy to keep my bones healthy and strong - Beckie Z. - Seattle, Washington

I just turned 50 years old and had terrible aches and pains in my knees and back. I have been taking Flexcerin™ for about 6 months and my knees and back feel great. I decided to give Bonexcin™ a try to help build  my bones and I am concerned about fractures. It seems to have helped to increase my bone mass. My doctor said he saw some improvement in my DEXA scan. Flexcerin™ and Bonexcin™ has really helped me. - Marilee A, Topeka, Kansas

My daughter knows that I was worried about the possibility of fracturing bones because my mother had problems as she got older. She suggested I try Bonexcin™ because her mother-in-law was taking it and has been raving about it. I have been using Bonexcin™ for about 1 month and I have to say that I feel stronger and I am no longer worried. I know that I am protecting my bones. - Jessica H., Albany, NY

I recently had a physical my doctor recommended I starting taking a bone support product. I just started menopause I am at a higher risk for brittle bones and fractures. I started taking Menoquil™ for my horrible night sweats and hot flushes and it has made a world of difference. I also started taking Bonexcin™ every day. I feel awesome, my hot flushes and night sweats are gone! Plus I know I am getting the best protection for my bones. I asked my pharmacist about Bonexcin™ and he told me it has all the ingredients I need to maintain overall bone health. - Victoria H. - Montreal

I take Avandia for diabetes and it keeps me well controlled. However, one of the side effects is possible bone loss. I have been taking Bonexcin™ for the past couple of months and I really feel that it has helped counteract the bone loss possibility. Bonexcin™ contains all the vitamins, minerals and ingredients I need to keep my bones healthy. Thanks! - Dave G., Miami

Supplement Facts - Bonexcin™
Serving Size: 2
Servings Per Container: 90
	Amount Per Serving	% Daily Value
Calcium Phosphate	1000 mg
Vitamin D (Cholecalciferol)	200 IU	25%
Ipriflavone	400 mg
Magnesium Oxide	400 mg
Phosphorus (from DCP)	400 mg
Green Tea Extract (50% Polyphenols)	200 mg
Vitamin K2 (menaquinone)	45 mcg
Zinc Oxide	5 mg
Manganese	2 mg
Folic Acid	900 mcg
Boron	2 mg
Copper	2 mg
Selenium	70 mcg
Other Ingredients: Stearic Acid, Microcrystalline Cellulose, Silica, Magnesium Stearate

Calcium

Calcium - the most abundant mineral in the human body. Calcium is extremely important in healthy bone formation and support. More than 99% of total body calcium is stored in the bones and teeth where it functions to support their structure. In older adults, particularly among postmenopausal women, bone loss occurs faster than bone formation, which increases the risk for osteoporosis. Osteoporosis is a disorder characterized by porous, fragile bones. It is a serious public health problem for more than 10 million Americans, 80% of whom are women. Another 34 million Americans have osteopenia, or low bone mass, which precedes osteoporosis. Osteoporosis is a concern because of its association with fractures of the hip, vertebrae, wrist, pelvis, ribs, and other bones.

Taking calcium 1000mg/day orally is effective for preventing and treating bone loss and osteoporosis.

• McGarry KA, Kiel DP. Postmenopausal osteoporosis. Strategies for preventing bone loss, avoiding fracture. Postgrad Med 2000;108:79-82,85-88, 91.
• Bryant RJ, Cadogan J, Weaver CM. The new dietary reference intakes for calcium: implications for osteoporosis. J Am Coll Nutr 1999;18:406S-412S.

Bone loss in premenopausal women over age 40 can be reduced significantly by supplementing with calcium.

• Bryant RJ, Cadogan J, Weaver CM. The new dietary reference intakes for calcium: implications for osteoporosis. J Am Coll Nutr 1999;18:406S-412S

The typical rate of bone loss in postmenopausal women who are not taking calcium supplements is 2% per year.

• Nieves JW, Komar L, Cosman F, Lindsay R. Calcium potentiates the effect of estrogen and calcitonin on bone mass: review and analysis. Am J Clin Nutr 1998;67:18-24.
• Kanis JA. The use of calcium in the management of osteoporosis. Bone 1999;24:279-90.

Despite the "first year effect" it is estimated that 30 years of continuous calcium supplementation after menopause might result in a 10% improvement in bone mineral density, and a 50% overall reduction in fracture rates, compared with women who do not take calcium supplements.

• Chiu KM. Efficacy of calcium supplements on bone mass in postmenopausal women. J Gerontol A Biol Sci Med Sci 1999;54:M275-80.

The combination of calcium 1000mg  plus vitamin D did significantly reduce the risk of hip fractures by about 29%.

• Jackson RD, LaCroix AZ, Gass M. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669-83.

Calcium has additive effects on bone density with other agents such as vitamin D, estrogens, or calcitonin. Whereas calcium alone generally reduces or prevents loss of bone density, combination with other agents can produce small increases in bone density ranging from 0.3% to 3.3% depending on the combination and dosages used.

• Baeksgaard L, Andersen KP, Hyldstrup L. Calcium and vitamin D supplementation increases spinal BMD in healthy, postmenopausal women. Osteoporos Int 1998;8:255-60.
• Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997;337:670-6.
• Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 1992;327:1637-42.
• Chiu KM. Efficacy of calcium supplements on bone mass in postmenopausal women. J Gerontol A Biol Sci Med Sci 1999;54:M275-8
• McGarry KA, Kiel DP. Postmenopausal osteoporosis. Strategies for preventing bone loss, avoiding fracture. Postgrad Med 2000;108:79-82,85-88, 91.
• Nieves JW, Komar L, Cosman F, Lindsay R. Calcium potentiates the effect of estrogen and calcitonin on bone mass: review and analysis. Am J Clin Nutr 1998;67:18-24.
• Kanis JA. The use of calcium in the management of osteoporosis. Bone 1999;24:279-90.

Ipriflavone

Ipriflavone - Is a synthetic isoflavone derivative of Genistein or daidzein. Genistein and daidzein are unique plant compounds called isoflavones, which are primarily found in soy products. Isoflavones belong to a larger category known as flavonoids, which are natural plant components that have antioxidant, anti-inflammatory, anti-allergy, and anticancer properties.

Taking ipriflavone orally in combination with calcium daily can prevent loss of bone mineral density (BMD) in postmenopausal women with osteoporosis or low bone mass.

• Ohta H, Komukai S, Makita K, et al. Effects of 1-year ipriflavone treatment on lumbar bone mineral density and bone metabolic markers in postmenopausal women with low bone mass. Horm Res 1999;51:178-83.
• Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-
• Gennari C, Adami S, Agnusdei D, et al. Effect of chronic treatment with ipriflavone in postmenopausal women with low bone mass. Calcif Tissue Int 1997;61,Suppl 1:S19-22.
• Gennari C, Agnusdei D, Crepaldi G, et al. Effect of ipriflavone-a synthetic derivative of natural isoflavones-on bone mass loss in the early years after menopause. Menopause 1998;5:9-15.
• Agnusdei D, Crepaldi G, Isaia G, et al. A double blind, placebo-controlled trial of ipriflavone for prevention of postmenopausal spinal bone loss. Calcif Tissue Int 1997;61:142-7.
• Agnusdei D, Zacchei F, Bigazzi S, et al. Metabolic and clinical effects of ipriflavone in established post-menopausal osteoporosis. Drugs Exp Clin Res 1989;15:97-104.

Taking Ipriflavone plus calcium or vitamin D prophylactically also seems to help prevent osteoporosis in postmenopausal women.

• Gambacciani M, Ciaponi M, Cappagli B, et al. Effects of combined low dose of the isoflavone derivative ipriflavone and estrogen replacement on bone mineral density and metabolism in postmenopausal women. Maturitas 1997;28:75-81.
• Ushiroyama T, Okamura S, Ikeda A, et al. Efficacy of ipriflavone and 1 alpha vitamin D therapy for the cessation of vertebral bone loss. Int J Gynaecol Obstet 1995;48:283-8.

Vitamin D

Vitamin D - is essential for promoting calcium absorption in the gut and maintaining adequate serum calcium and phosphate concentrations to enable normal mineralization of bone. Vitamin D is necessary for bone growth and remodeling. Without sufficient vitamin D, bones can become thin, brittle, or misshapen. Together with calcium, vitamin D also helps protect older adults from osteoporosis.

Taking cholecalciferol (vitamin D3) orally with calcium supplements can decrease postmenopausal bone loss, help prevent osteoporosis, and decrease the risk of primary prevention of fractures.

• Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997;337:670-6.
• Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 1992;327:1637-42.
• Minne HW, Pfeifer M, Begerow B, et al. Vitamin D and calcium supplementation reduces falls in elderly women via improvement of body sway and normalization of blood pressure: a prospective, randomized, and double-blind study. Abstracts World Congress on Osteoporosis 2000.
• Chapuy MC, Pamphile R, Paris E, et al. Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int 2002;13:257-64.
• NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA 2001;285:785-95.
• National Osteoporosis Foundation. Physician's Guide to Prevention and Treatment of Osteoporosis. Universal Recommendations for All Patients. Available at: http://www.nof.org/physguide/univeral_recommendations.htm#adequate. (Accessed 14 May 2005).
• Larsen ER, Mosekilde L, Foldspang A. Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: a pragmatic population-based 3-year intervention study. J Bone Miner Res 2004;19:370-8.
• Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005;293:2257-64.
• Boonen S, Body JJ, Boutsen Y, et al. Evidence-based guidelines for the treatment of postmenopausal osteoporosis: a consensus document of the Belgian Bone Club. Osteoporos Int 2005;16:239-54.
• Papadimitropoulos E, Wells G, Shea B, et al. Meta-analyses of therapies for postmenopausal osteoporosis. VIII: Meta-analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women. Endocr Rev 2002;23:560-9.

Magnesium

Magnesium - is a mineral that is essential to many biological processes that occur in the body. Magnesium aids in the body’s absorption of calcium and also plays a key role in the strength and formation of bones and teeth. This means that those at risk for osteoporosis can benefit from taking magnesium.Magnesium is essential for the development and maintenance of healthy bones. It works together with calcium and vitamin D to help keep bones strong and prevent osteoporosis.

There is preliminary evidence that suggests taking magnesium orally might prevent bone loss in postmenopausal osteoporosis.

• Stendig-Lindberg G, Tepper R, Leichter I. Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporsis. Magnes Res 1993;6:155-63.

In another study of postmenopausal women who were also taking estrogen, magnesium 600 mg plus calcium 500 mg and a multivitamin supplement daily increased bone mass better than estrogen alone.

• Abraham GE, Grewal H. A total dietary program emphasizing magnesium instead of calcium. Effect on the mineral density of calcaneous bone in postmenopausal women on hormonal therapy. J Reprod Med 1990;35:503-7.